Organotiniv carboxylates as promising potential drug candidates in the field of cancer chemotherapy. Organotin compounds or stannanes are chemical compounds based on tin with hydrocarbon substituents. In 1852, lowich reported on the reaction of alkyl halides with a tinsodium alloy giving alkyltin compounds 2. Organotin chemistry wiley online books wiley online library. The crystal and molecular structure of nbu2sn2meoc6h4coo2o2. If the inline pdf is not rendering correctly, you can download the pdf file here. Research article synthesis, characterization, semiempirical and biological activities of organotiniv carboxylates with 4piperidinecarboxylic acid shabbirhussain, 1 saqibali, 2 sairashahzadi, 2 sarojk. The hemolytic activity of the complexes was lower compared to tritonx 100 positive control, 100% lysis and higher than phosphatebuffered saline negative control, 0% lysis. The area grew rapidly in the 1900s, especially after the discovery of the grignard reagents, which are. The second, completely revised edition of this comprehensive standard reference. Based on spectroscopic evidence ir and nmr, all the triorganotin carboxylates. Carboxylate definition of carboxylate by the free dictionary. This should include, the wiley titles, and the specific portion of the content you wish to reuse e.
The complexes exhibited comparatively higher hemolytic activity as compared to free ligand. High yield of the products can be achieved by the azeotropic reflux of the reactants in boiling toluene using a dean and stark separator. Antibiotic resistance is another leading problem because of various types of bacterial strains. Method 5504, issue 2 dated 15 august 1994 page 3 of 6 niosh manual of analytical methods nmam, fourth edition, 81594 5. The organic group may be an alkyl chain or an aromatic ring. The organotin chlorides are very convenient starting materials for the synthesis of the organotin cyanides, azides, isocyanates and isothiocyanates from the appropriate metal salts equations 143146. Organotiniv complexes with ons donor schiff base ligand. Pdf synthesis, characterization, semiempirical and biological. Organotin mercapto ethylene carboxylates and method for. Synthesis and spectroscopic properties of diorganotiniv complexes with oanisic acid. Synthesis, characterization, semiempirical and biological.
Spectroscopic and xray structural characterization of new organotin carboxylates and their in vitro antifungal activities. It is well known that the organotin carboxylates have versatile. Organotin definition of organotin by the free dictionary. Sharma, 3 kushalqanungo, 3 andmuhammadshahid 4 department of chemistry, gc university, faisalabad, pakistan. Organotin chemistry is part of the wider field of organometallic chemistry. The effects of organotin catalysts on hydrolytic condensation of. His work has covered the interconnecting themes of organic peroxides, organometallic chemistry, free radical chemistry, and the organic and organometallic applications of esr spectroscopy, and his published work includes a book on organic peroxides 1961, and the first edition of organotin chemistry 1997. The structures of these complexes are discussed on the basis of ir, multinuclear 1h, c and 119sn nmr. The organotiniv carboxylates displayed powerful antimicrobial activities against. Application as single source precursor for deposition of tin oxide thin films and evaluation of biological activities arshad farooq butt department of chemistry, allama iqbal open university, islamabad, pakistan.
Additionally, photosensitivity was found to be linearly related to free radical stability of the hydrocarbon group. Compositions comprising an organotin mercaptide, organotin sulfide, organotin carboxylate or mixtures thereof and a diester of an ethylenically unsaturated dicarboxylic acid having one carboxyl group on each carbon atom of the ethenylene group are useful for stabilizing halogencontaining organic polymers against the deteriorative effects of heat, light and weathering. Organotiniv carboxylates of cyclopropane carboxylic acid. They are widely used in two component urethane systems such as casting systems, high performance coatings and in the synthesis of onecomponent moisture cure urethane prepolymers for coatings. Newly designed organotiniv carboxylates with peptide. The structures of these l compounds have been evaluated by various analytical techniques such as elemental analysis, multinuclear nmr 1h, c and 119sn and mass spectrometry. Koji nemoto, yoshiaki hirano, keiichi hirata, tsukasa takahashi, hideaki tsuneki, kenichi tominaga, kazuhiko sato. Pdf organotin iv carboxylates with the general formulae r2sncll r me. Saponification of the stearate sample yielded a tincontaining residue which was insoluble in all the. Thanks for helping us catch any problems with articles on deepdyve. Antifungal activity of organotin compounds with functionalized carboxylates evaluated by the microdilution bioassay in vitro. The field of organotin chemistry has a long history that started since 1849, when frankland isolated a specimen of diethyltin diiodide 1. Atrftir spectroscopy detects alterations induced by. With tweezers, carefully transfer the filter to a 125ml beaker.
There are four main groups of organotin compounds, depending on the number of organic groups contained. The triphenyltiniv product 3 showed interaction with salmon sperm dna and was found to be the most active antimicrobial agent having the lowest hemolytic effects. The first organotin compound was diethyltin diiodide c 2 h 5 2 sni 2, discovered by edward frankland in 1849. In contrast to sulfurcontaining tin compounds, tin carboxylates have to be used with antioxidants. Department of chemistry, allama iqbal open university islamabad 44000, pakistan. They are however less efficient as heat stabilizers than the sulphurcontaining organotin mercaptides. The organotiniv complexes displayed lower cytotoxic effects 12. Read newly designed organotiniv carboxylates with peptide linkage. Thremogravimetric tg studies of a new series of organotiniv carboxylates of the general formula r n snl 4n where r ch 3, c 2 h 5, c 4 h 9, c 6 h 5, c 6 h 11 and c 8 h 17, n 2, 3 and l paramethoxyphenylethanoate anion have been carried out. They are however less efficient as heat stabilisers than the sulphurcontaining organotin mercaptides. Lowline edge roughness extreme ultraviolet photoresists. Amide based organotiniv carboxylates may be one of the better alternate drug against leishmaniasis.
Organotiniv complexes of carboxylic acid derivatives in. In most of these systems, a solvent is used to reduce the viscosity to assist application. Recently, interests in organotiniv carboxylates are increasing due to. Thus by using organotin carboxylate for clinical medicine, cost reduction. Synthesis, characterization and antimicrobial evaluation. Pdf organotiniv carboxylates as promising potential. Ch3 o snch2ch2ch2 ch33 n n och2ch3 ch3ch2ch2ch23sn n s och 2ch3 ch 3ch 2ch 2ch23sn o n ch 3ch2ch ch sn cooch2 n n cl snch2ch2ch2ch33 cl ch 3ch sn o ch32cho n n ch ch2 sn och 3 n och2ch3 snch2ch2ch2ch33 n s och3 ch 3ch 2ch ch sn. Pdf synthesis and biological activities of organotin iv. Prepare a standard mixture of the organotin compounds of interest. Tin in the form of a metal and its alloys were known to the ancient people and have greatly affected the course of human history. Organotin iv carboxylates as promising potential drug candidates in the field of cancer chemotherapy. The compounds generally exhibit greater fungitoxicity than the diorganotiniv dichlorides and the carboxylic acids from which. Synthesis, characterization, biological activities.
Organotin carboxylates are generally prepared by the reaction of organotin oxide or hydroxide with carboxylic acids. Pdf organotin carboxylate catalyst in urethane formation. The advantage of the use of sulfur free stabilizers is the good photostability and the lack of odor. Synthesis spectroscopic characterization and biological activities volume. Complete patent searching database and patent data analytics services. Organotiniv complexes of carboxylic acid derivatives. Pdf organotiniv carboxylates as promising potential drug.
Horowitz and metzger method has been used to calculate thermokinetic parameters. Organotin carboxylates are important catalysts in aliphatic urethane synthesis. In this context, metal based drugs like organotiniv may play an. Pdf medicinal inorganic chemistry plays an important role in exploring the properties of metal ions for the designing of new drugs. Organotin chemistry, 2nd, completely revised and updated. Germatranes, diethyltin, tribenzyltin, spectroscopy, antileishmanial activity. Organotins are organometallic compounds based on organic derivatives of the. The convention prohibits the new application of listed antifouling systems and it imposes a requirement that organotin biocides be removed from hulls or overcoated to prevent leaching note.
Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations, european journal of medicinal chemistry on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Synthesis, chemical characterization and biological. Organotin methyl and butyl toxicity occurrence tin sn is a silver metal atomic number 50 that occurs in the earths crust mainly as cassiterite or tinstone sno2 which is the main source of tin. Mass spectroscopic and biological activity investigations. Synthesis and antifungal activity of some organotiniv. Six diorganotiniv carboxylates prepared by reacting diorganotiniv dichlorides with the respective silver carboxylate have been tested for antifungal activity against aspergillus. The sulphur free organotin carboxylates, and in particular tin maleates, confer excellent light stability to finished goods intended for outdoor applications. Brainard lowline edge roughness extreme ultraviolet photoresists of organotin carboxylates, journal of micro. We must point out that for all three tested organotin carboxylates mic 100% values were fixed as distinct from mic 50% values for fluconazole.
Organotiniv derivatives of amidebased carboxylates. Synthesis, characterization, semiempirical and biological activities. Common alkyl chains are butyl or octyl, and a common aromatic ring is phenyl. In the final step the remaining chloride anions can be substituated by the desired anion e. Davies has updated the contents of his book to reflect the current state of research into organotin chemistry. Among the organotins, organotin carboxylates are important.
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